A DIGE PROTEOMIC ANALYSIS FOR LOW-INTENSITY EXERCISE-TRAINED RAT SKELETAL MUSCLE
نویسندگان
چکیده
منابع مشابه
Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle.
Skeletal muscle aging is associated with a loss in tissue mass and contractile strength, as well as fiber type shifting and bioenergetic adaptation processes. Since mitochondria represent the primary site for energy generation via oxidative phosphorylation, we investigated potential changes in the expression pattern of the mitochondrial proteome using the highly sensitive DIGE approach. The com...
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Sarcopenia is the drastic loss of skeletal muscle mass and strength during ageing. In order to better understand the molecular pathogenesis of age-related muscle wasting, we have performed a DIGE analysis of young adult versus old rat skeletal muscle. Proteomic profiling revealed that out of 2493 separated 2-D spots, 69 proteins exhibited a drastically changed expression. Age-dependent alterati...
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Endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and mitochondrial biogenesis were assessed following varying intensities of exercise training. The animals were randomly assigned to receive either low- (LIT, n=7) or high intensity training (HIT, n=7), or were assigned to a control group (n=7). Over 5 weeks, the animals in the LIT were exercised on a treadmill with a 10° incli...
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throughout a lifetime is essential for a favorable quality of life. Like most human tissue, skeletal muscle is highly plastic and is capable of responding to a stimulus through a network of anabolic signaling which results in growth and increases in strength. Skeletal muscle functions as the largest disposal site of ingested glucose 1, plays an important role in lipid oxidation 2, 3, and is one...
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ژورنال
عنوان ژورنال: Japanese Journal of Physical Fitness and Sports Medicine
سال: 2011
ISSN: 0039-906X,1881-4751
DOI: 10.7600/jspfsm.60.511